Journal
ORGANIC LETTERS
Volume 19, Issue 19, Pages 5320-5323Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02608
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Funding
- Russian Science Foundation [17-14-01065]
- Russian Science Foundation [17-14-01065] Funding Source: Russian Science Foundation
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The first representatives of a new group of manzamine-related alkaloids with a previously unknown skeletal systems, namely, lissodendoric acids A (1) and B (2), were isolated from the sponge Lissodendoryx florida collected from the Sea of Okhotsk. The structures and absolute configurations have been elucidated by extensive spectroscopic analysis together with chemical transformations and quantum-chemical modeling. The lissodendoric acids show a potent capability to decrease the production of reactive oxygen species in neuroblastoma Neuro 2a and somewhat increase the survival of these cells upon treatment with 6-hydroxydopamine (an in vitro antiparkinson biotest).
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