Journal
ORGANIC LETTERS
Volume 19, Issue 19, Pages 5014-5017Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01840
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Funding
- Department of Science and Technology - Science and Engineering Research Board New Delhi, India [DST-SERB-EMR/2016/1000952]
- Indian Institute of Technology Hyderabad (IITH)
- CSIR, New Delhi, India
- UGC, New Delhi, India
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Organoiodine(III)-promoted C(sp(3))-H azidation was a key step for the cycloaminative process. An unprecedented method for metal-free dehydrogenative N-incorporation into C(sp(3))-H and C(sp(2))-H bonds for the synthesis of diverse imidazoles has been disclosed. The overall transformation involves the construction of four C-N bonds through hydroamination-azidation-cyclization sequence. The reaction can be easily handled and proceeds under mild conditions. Further, the potential of the present strategy is revealed by the practical synthesis of N-heterocyclic carbene (NHC) precursors.
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