Intramolecular, Site-Selective, Iodine-Mediated, Amination of Unactivated (sp3)C-H Bonds for the Synthesis of Indoline Derivatives

The Iodine-mediated oxidative intramolecular amination of anilines via cleavage of unactivated (sp(3))C-H and N-H borids for the production of indolines is described, This transition-metal-free approach provides a straightforward strategy for producing (Sp(3))C-N bonds for use in the preferential functionalization of unactivated (sp(3))C-H bonds Over (sp(2))C-H bonds. The reaction could be performed on a gram scale for the synthesis of functionalized indolines.