4.8 Article

A Fe(III)/NaBH4-Promoted Free-Radical Hydroheteroarylation of Alkenes

Journal

ORGANIC LETTERS
Volume 19, Issue 24, Pages 6463-6465

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03313

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Funding

  1. National Natural Science Foundation of China [21672089, 21472080]
  2. Natural Science Foundation of the Jiangsu Higher Education Institutions of China [17KJA350001]

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A free-radical-mediated intermolecular hydroheteroarylation of simple alkenes was developed. Through simply mixing heteroarenes, alkenes, Fe(III), and NaBH4 at 0 degrees C together, a wide range of alkylated heteroarenes could, be afforded in moderate to excellent yields within 1 h.

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