4.8 Article

Dual Role of H2O2 in Palladium-Catalyzed Dioxygenation of Terminal Alkenes

Journal

ORGANIC LETTERS
Volume 19, Issue 13, Pages 3354-3357

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01228

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Funding

  1. National Program on Key Research Project [2016YFA0602900]
  2. National Natural Science Foundation of China [21420102003, 21672072]
  3. Fundamental Research Funds for the Central Universities [2015ZY001, 2017ZD062]

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A pallaclium-catalyzed, environmentally friendly dioxygenation reaction of simple alkenes has been developed that enabled rapid assembly of valuable a-hydroxy ketones with high atom economy. Notably, control experiments and 180 isotope-labeling experiments established that H2O2 played a dominant dual role in this transformation.

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