4.8 Article

Chiral Macrocyclic Organocatalysts for Kinetic Resolution of Disubstituted Epoxides with Carbon Dioxide

Journal

ORGANIC LETTERS
Volume 19, Issue 15, Pages 4070-4073

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01838

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Funding

  1. JSPS KAKENHI [JP16H01030]

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Among chiral macrocycles 1 synthesized, lm with the 3,5-bis(trifluoromethypphenylethynyl group was the best organocatalyst for the enantioselective synthesis of cyclic carbonates from disubstituted or monosubstituted epoxides and CO2. The X-ray crystal structure of lm revealed a well-defined chiral cavity with multiple hydrogen-bonding sites that is suitable for the enantioselective activation of epoxides. A catalytic cycle proposed was supported by DFT calculations.

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