Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 27, Pages 5790-5796Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01237c
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Funding
- University Cancer Research Fund
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Tricyclic biaryls are important scaffold structures in many natural products and lead compounds in drug discovery. The formation of a biaryl unit is often the key step for the synthesis of tricyclic biaryls. Despite significant progress toward the synthesis of biaryl compounds in recent years, the direct cross-coupling of two different aryl halides is still challenging and robust methods are lacking. Herein we report a direct cross-coupling of two different aryl halides in the presence of a palladium catalyst and boron ester, which provides a new and useful complementary method to synthesize tricyclic biaryls.
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