Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 28, Pages 6033-6041Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01149k
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Funding
- National Natural Science Foundation of China [21572200]
- Fundamental Research Funds for the Central Universities [2017QNA3013]
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A highly enantioselective aza-Friedel-Crafts reaction of N-sulfonyl cyclic ketimines with indoles catalyzed by chiral phosphoric acids has been developed. This methodology provides an efficient and facile route to indole-containing chiral cyclic alpha-amino acid derivatives bearing a quaternary stereocenter in high yields and up to 98% enantioselectivity.
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