4.6 Article

Sulfinyl isobutyramide as an auxiliary for palladium(II)-catalyzed C-H arylation and iodination of benzylamine derivatives

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 23, Pages 4966-4970

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01163f

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Funding

  1. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
  2. National 1000 Youth Talents Program
  3. 100 Talents Program of Fujian Province
  4. State Key Laboratory of Structural Chemistry

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A novel readily available bidentate 2-methylsulfinyl isobutyramide directing group has been developed for benzylamine derivatives. It promoted ortho-C-H arylation and iodination of various substrates in good to excellent yields. The auxiliary is promising to be used in organic synthesis due to its versatility and convenient preparation from inexpensive materials.

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