Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 34, Pages 7127-7130Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01801k
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Funding
- National Natural Science Foundation of China [21172001, 21372008]
- Natural Science Foundation of Education Administration of Anhui Province [KJ2016A267]
- Special and Excellent Research Fund of Anhui Normal University
- Doctoral Scientific Research Foundation of Anhui Normal University [2016XJJ110]
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A novel and efficient strategy for the synthesis of 2-hydroxy-6-oxocyclohex- 1-enecarboxamides through a Rh-2(OAc)(4)-catalyzed direct carboxamidation of cyclic 2-diazo-1,3-diketones has been developed. The method features readily available starting materials, easy scalability, mild reaction conditions and a simple work-up for product isolation, which makes this strategy highly attractive. A tentative mechanism involving an isocyanide insertion and hydrolysis sequence for this reaction is proposed.
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