4.6 Review

Recent progress in mild Csp3-H bond dehydrogenative or (mono-) oxidative functionalization

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 6, Pages 1294-1312

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02474b

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Funding

  1. Borheringer Ingelheim Stiftung
  2. Deutsche Forschungsgemeinschaft (DFG)

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Over the past few years, the development of oxidative methodologies towards efficient and selective direct Csp(3)-H bond functionalization processes has attracted tremendous attention from synthetic chemists. However, only a little attention has been given to the key role of the nature of the oxidant. This review aims at providing a brief summary of the recent advances in mild and more benign oxidative Csp(3)-H bond functionalization reactions, which are classified according to the type of oxidation system employed.

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