Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 3, Pages 598-604Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02384c
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Funding
- General Program of the National Natural Science Foundation of China [21271003, 21271004, 51432001, 51472002]
- Science and Technology Plan of Anhui Province [1604b0602016]
- Ministry of Education of the People's Republic of China
- Higher Education Revitalization Plan Talent Project of Anhui Province
- Undergraduate Training Program for Innovation and Entrepreneurship of Anhui University [201610357007]
- Undergraduate Training Program for Scientific Research of Anhui University
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A triphenylamine-pyridine derivative, viz., a fluorescence probe was designed and synthesized. The probe displayed an on-off-on fluorescence switch, upon the sequential addition of Cu2+ and ethylenediaminetetraacetic acid (EDTA). The detection mechanism was confirmed by using UV-vis, fluorescence and H-1 NMR titration spectra. Interestingly, the probe can accumulate in mitochondria, and thus detect Cu2+ in real-time there, which indicated that probe L can be used to monitor intracellular mitochondrial Cu2+ levels. Further understanding of the biological functions of Cu2+ in mitochondria has important implications for treating cancer and other diseases.
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