Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 20, Pages 4286-4290Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00906b
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Funding
- Qingdao University
- National Natural Science Foundation of China [21672121, 21502043]
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A NHC-catalyzed 1,3-dipolar cycloaddition reaction of allyl ketones with azides has been developed. This strategy could generate 1,4,5-trisubstituted 1,2,3-triazoles in high yields and regioselectivities in the presence of a 20 mol% N-heterocyclic carbene catalyst. A broad substrate scope of this process is also presented.
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