Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 42, Pages 8929-8935Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02187a
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Funding
- National Natural Scientific Foundation of China [21472107, 21372142]
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A novel silver-catalyzed decarboxylative acylation of alpha-oxo-carboxylic acids was developed, by which various 3-acyl quinoxalin-2(1H)-ones were synthesized by direct C-H bond acylation of quinoxalin-2(1H)-ones. In this method, alpha-oxo-carboxylic acids served as efficient acylating reagents to in situ generate the required active acyl radical. Its excellent chemoselectivity allowed the molecular diversity of 3-acyl quinoxalin-2(1H)-ones to be achieved by convenient functionalizations of both N1- and C3-positions.
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