Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 6, Pages 1346-1349Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00063d
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Funding
- US National Institutes of Health [GM087460]
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Sulfonates are frequently used to endow water solubility on hydrophobic molecules, but the repertoire of sulfonate protecting groups remains limited. Here we describe the first sulfonate esters that can be unmasked by the mild reducing conditions found in live mammalian cells. Self-immolative cleavage releases the sulfonate and the two-electron reduction product of a thioquinone methide.
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