4.6 Article

Phosphine-catalyzed Friedel-Crafts reaction of naphthols with para-quinone methides: expedient access to triarylmethanes

Journal

ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 23, Pages 4941-4945

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00911a

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Funding

  1. National Natural Science Foundation of China [21672067, 21572065, 21425205, 21372084]
  2. 973 Programs [2011CB808600]
  3. Shanghai Pujiang Program [14PJ1403100]
  4. Changjiang Scholars and Innovative Research Team in University (PCSIRT)

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We developed a novel phosphine-catalyzed Friedel-Crafts reaction of naphthols with para-quinone methides (p-QMs). This reaction provided a promising method for the synthesis of triarylmethanes, which widely exist in natural products and in molecules which have been shown to have biological and pharmacological activity.

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