Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 44, Pages 9331-9351Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02182h
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- Fondazione Cariplo
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A new and short fragment-based approach towards artificial (but natural-based) complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The resulting library of compounds has been tested for its capacity to inhibit beta-amyloid protein aggregation, as a possible strategy to develop new chemical entities to be used as prevention or therapy for Alzheimer's disease. Some of the members of this library have demonstrated, in thioflavin assays, a highly promising activity in inhibiting aggregation for two beta-amyloid peptides: A beta 1-42 and the truncated A beta pE3-42.
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