Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 38, Pages 8145-8152Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01874f
Keywords
-
Categories
Funding
- Core Research for Evolutional Science and Technology (CREST) program of the Japan Science and Technology Agency (JST)
- JSPS KAKENHI [15K08024]
- Platform Project for Supporting Drug Discovery and Life Science Research from the Japan Agency for Medical Research and Development (AMED)
- Grants-in-Aid for Scientific Research [15K08024] Funding Source: KAKEN
Ask authors/readers for more resources
We designed and synthesized a novel artificial 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA/LNA) with a phenoxazine nucleobase and named this compound BNAP. Oligodeoxynucleotide (ODN) containing BNAP showed higher binding affinities toward complementary DNA and RNA as compared to ODNs bearing 2',4'-BNA/LNA with 5-methylcytosine or 2'-deoxyribonucleoside with phenoxazine. Thermodynamic analysis revealed that BNAP exhibits properties associated with the phenoxazine moiety in DNA/DNA duplexes and characteristics associated with the 2',4'-BNA/LNA moiety in DNA/RNA duplexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
