Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 37, Pages 7796-7801Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01924f
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Funding
- National Natural Science Foundation of China [81602959, 81473074, 81673291]
- Science Foundation of Zhejiang Sci-Tech University [16062192-Y]
- Arthritis & Chronic Pain Research Institute, USA
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A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.
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