Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 21, Pages 4540-4543Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00430c
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Funding
- National Institutes of Health [GM110208, GM122459]
- Egyptian government
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Cyclic peptides are capable of binding and modulating challenging drug targets including protein-protein interactions. However, their lack of membrane permeability prevents their application against intracellular targets. In this study, we show that it is possible to design a cell-permeable and biologically active cycloheptapeptide inhibitor against the intracellular enzyme peptidyl-prolyl isomerase Pin1 by integrating cell-penetrating and target-binding sequences.
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