Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 24, Pages 5227-5235Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00799j
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Funding
- Science Foundation Ireland (SFI) [14/TIDA/2471]
- Irish Research Council (IRC) [GOIPG/2014/1075]
- Science Foundation Ireland (SFI) [14/TIDA/2471] Funding Source: Science Foundation Ireland (SFI)
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Herein we report a two-step sequence for the preparation of amides starting from azides and enolisable aldehydes. The reaction proceeded via the formation of triazoline intermediates that were converted into amides via Lewis acid catalysis. Preliminary studies on the preparation of triazolines under chiral phase transfer catalysis are also presented, demonstrating that enantioenriched amides could be prepared from achiral aldehydes in moderate to low enantioselectivity.
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