Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 22, Pages 4907-4920Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00774d
Keywords
-
Categories
Funding
- University of Ferrara (fondi FAR)
Ask authors/readers for more resources
The synthesis of a small collection of novel bile acid-bisphosphonate (BA-BP) conjugates as potential drug candidates is reported. The disclosed methodology relied on the installation of azide and thiol functionalities at the head and tail positions, respectively, of the BA scaffold and its subsequent decoration by orthogonal click reactions (copper-catalyzed azide-alkyne cycloaddition, thiol-ene or thiol-yne coupling) to introduce BP units and a fluorophore. Because of the troublesome isolation of the target conjugates by standard procedures, the methodology culminated with the functionalization of the BA scaffold with a light fluorous tag to rapidly and efficiently purify intermediates and final products by fluorous solid-phase extraction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available