Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 15, Issue 21, Pages 4595-4600Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00816c
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Funding
- Japan Society for the Promotion of Science [15H03836]
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [15H00809, 25104512]
- Toyota Physical & Chemical Research Institute
- Division of Instrumental Analysis, Life Science Research Centre, Gifu University
- Grants-in-Aid for Scientific Research [15H00809, 25104512, 15H03836, 17H00769] Funding Source: KAKEN
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We describe the construction of peptide-carbohydrate conjugates, namely glycopeptides, capable of self-assembling in water. We found that disaccharide structures (epimer or glycosidic-bond geometry) appended to the glycopeptides have a noticeable effect on the hydrogel formation ability as well as the morphology of the self-assembled structures. The soft materials consisting of self-assembled structures with carbohydrates on their surface and various types of morphologies might be useful as matrices to investigate the function of carbohydrates in biological events.
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