Journal
HEPATIC ONCOLOGY
Volume 5, Issue 1, Pages -Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/hep-2017-0023
Keywords
beta-catenin; hemorrhage; hepatocellular adenoma; hepatocellular carcinoma; HNF1A; inflammation; malignant transformation; molecular classification; oral contraception; sonic hedgehog
Categories
Funding
- Association pour la recherche contre le cancer
- Societe Nationale Francaise de Gastro-Enterologie
- Inca
- GENTHEP Inserm Network
- Equipe Labellisee Ligue Contre le Cancer
- Labex OncoImmunology Investissement d'Avenir
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Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10-20%) and malignant transformation into hepatocellular carcinoma (<5%). A molecular classification has been recently updated in six major subgroups, linked to risk factors, histology, imaging and clinical features: adenomas inactivated for HNF1A, inflammatory adenomas, -catenin-activated adenomas mutated in exon 3, -catenin-activated adenomas mutated in exon 7-8, sonic hedgehog adenomas, and unclassified adenomas. Indeed, -catenin-mutated adenomas in exon 3 are associated with malignant transformation, and sonic hedgehog adenomas with bleeding. This new nosology of hepatocellular adenomas will help to stratify patients according to risk of complications and will guide therapeutics in the future.
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