Journal
ORAL ONCOLOGY
Volume 68, Issue -, Pages 20-26Publisher
ELSEVIER
DOI: 10.1016/j.oraloncology.2017.03.003
Keywords
Autofluorescence; VELscope (R); Quantitative analysis; Oral cancer
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Funding
- Ministry of Health and Welfare, Taiwan of Taiwan [MOHW105-TDU-B-212-134007, MOHW105-TDU-B-212-112016]
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Objectives: VELscope (R) was developed to inspect oral mucosa autofluorescence. However, its accuracy is heavily dependent on the examining physician's experience. This study was aimed toward the development of a novel quantitative analysis of autofluorescence images for oral cancer screening. Materials and methods: Patients with either oral cancer or precancerous lesions and a control group with normal oral mucosa were enrolled in this study. White light images and VELscope (R) autofluorescence images of the lesions were taken with a digital camera. The lesion in the image was chosen as the region of interest (ROI). The average intensity and heterogeneity of the ROI were calculated. A quadratic discriminant analysis (QDA) was utilized to compute boundaries based on sensitivity and specificity. Results: 47 oral cancer lesions, 54 precancerous lesions, and 39 normal oral mucosae controls were analyzed. A boundary of specificity of 0.923 and a sensitivity of 0.979 between the oral cancer lesions and normal oral mucosae were validated. The oral cancer and precancerous lesions could also be differentiated from normal oral mucosae with a specificity of 0.923 and a sensitivity of 0.970. Conclusion: The novel quantitative analysis of the intensity and heterogeneity of VELscope (R) autofluorescence images used in this study in combination with a QDA classifier can be used to differentiate oral cancer and precancerous lesions from normal oral mucosae. (C) 2017 Elsevier Ltd. All rights reserved.
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