Journal
OPTICS LETTERS
Volume 42, Issue 7, Pages 1452-1455Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.42.001452
Keywords
-
Categories
Funding
- Research Grants Council of the Hong Kong Special Administrative Region [21205016]
- City University of Hong Kong (CityU) [7200474, 9610339]
- Shenzhen (China) Basic Research Project [JCYJ20160329150236426]
- National Natural Science Foundation of China (NSFC) [61235005]
- Natural Science Foundation of Guangdong Province [S2013030013302]
Ask authors/readers for more resources
Fast functional photoacoustic microscopy requires multiwavelength pulsed laser sources with high pulse repetition rates, short wavelength switching time, and sufficient pulse energies. Here, we report the development of a stimulatedRaman- scattering- based multi- wavelength pulsed laser source for fast functional photoacoustic imaging. The new laser source is pumped with a 532 nm 1 MHz pulsed laser. The 532 nm laser beam is split into two: one pumps a 5 m optical fiber to excite a 558 nm wavelength via stimulated Raman scattering; the other goes through a 50 m optical fiber to delay the 532 nm pulse by 220 ns. The two beams are combined and coupled into an optical fiber for photoacoustic excitation. As a result, the new laser source can generate 2 million pulses per second, switch wavelengths in 220 ns, and provide hundreds of nanojoules pulse energy for each wavelength. Using this laser source, we demonstrate optical- resolution photoacoustic imaging of microvascular structures and oxygen saturation in the mouse ear. The ultrashort wavelength switching time enables oxygen saturation imaging of flowing red blood cells, which is valuable for high- resolution functional imaging. (C) 017 Optical Society of America
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available