Journal
OPTICS EXPRESS
Volume 25, Issue 10, Pages 10791-10800Publisher
OPTICAL SOC AMER
DOI: 10.1364/OE.25.010791
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Funding
- Singapore National Research Foundation [NRF-NRFF2015-02]
- Ministry of EducationSingapore (MOE) Tier 1 Grant [RG180/16]
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We studied quantitative phase imaging (QPI) using coherent laser illumination coupled with static and moving optical diffusers. The spatial coherence of a continuous-wave laser was controlled by tuning the particle size and the diffusion angle of optical diffusers for speckle-reduced 3D phase imaging of transparent objects. We used a common-path QPI configuration to investigate the coherent phase mapping of polystyrene micro-beads and breast cancer cells (MCF-7) under different degrees of coherent speckles. The proposed speckle reduction method could provide an avenue for enhancing lateral resolution and suppressing coherent artifacts of the phase images from QPI. (C) 2017 Optical Society of America.
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