Journal
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
Volume 6, Issue 4, Pages 451-462Publisher
ELSEVIER INC
DOI: 10.1016/j.jcmgh.2018.07.004
Keywords
NAFLD; Obesity; Micronutrients; Vitamins; minerals; carotenoids
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Funding
- National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism [R01 AA026302-01, K08-AA021424]
- Robert Wood Johnson Foundation
- Harold Amos Medical Faculty Development Award [7158]
- Institute of Diabetes, Obesity and Metabolism Diabetes Research Center Pilot Award [P30 DK019525]
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We review the contribution of micronutrients to nonalcoholic fatty liver disease pathology and therapeutics. We examine the relevant data on minerals, vitamins, and carotenoids in nonalcoholic fatty liver disease experimental and human studies and offer insight into their use (or nonuse) therapeutically. Micronutrients include electrolytes, minerals, vitamins, and carotenoids, and are required in microgram or milligram quantities for cellular metabolism. The liver plays an important role in micronutrient metabolism and this metabolism often is altered in chronic liver diseases. Here, we review how the liver contributes to micronutrient metabolism; how impaired micronutrient metabolism may be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a systemic disorder of energy, glucose, and lipid homeostasis; and how insights gained from micronutrient biology have informed NAFLD therapeutics. Finally, we highlight some of the challenges and opportunities that remain with investigating the contribution of micronutrients to NAFLD pathology and suggest strategies to incorporate our understanding into the care of NAFLD patients.
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