Journal
JOURNAL OF CANCER
Volume 9, Issue 22, Pages 4156-4165Publisher
IVYSPRING INT PUBL
DOI: 10.7150/jca.27098
Keywords
lung cancer; lncRNA; EZH2; regulation; interaction
Categories
Funding
- National Natural Scientific Foundation of China [81802947, 81472595]
- Health and Family Planning Commission of Hunan Province [B20180545]
- Natural Science Foundation of Hunan Province [2017JJ2173, 2018JJ3314]
- Changsha Science and Technology Board [kq1706045]
Ask authors/readers for more resources
Lung cancer is the leading cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts and longer than 200 nucleotides. LncRNAs have been demonstrated to modulate gene expression at transcriptional, post-transcriptional, as well as epigenetic levels in lung cancer. Interestingly, compelling studies have revealed that lncRNAs participated in the EZH2 oncogenic regulatory network. EZH2 plays an important role in the initiation, progression and metastasis of cancer. On one hand, lncRNAs can directly bind to EZH2, recruit EZH2 to the promoter region of genes and repress their expression. On the other hand, lncRNAs can also serve as EZH2 effectors or regulators. In this review, we summarized the types of lncRNA-EZH2 interaction and regulatory network identified till date and discussed their influence on lung cancer. Better understanding regarding the interaction and regulatory network will provide new insights on lncRNA- or EZH2-based therapeutic development in lung cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available