Journal
PHARMACEUTICALS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ph11030084
Keywords
iron metabolism; infection; innate immunity; hepcidin; ferritin; anemia of inflammation; pharmaceutical targets
Categories
Funding
- European Regional Development Fund [Norte-01-0145-FEDER-000012] Funding Source: Medline
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/101405/2014, PTDC/IMI-MIC/1683/2014] Funding Source: Medline
- Fundação para a Ciência e a Tecnologia [PTDC/IMI-MIC/1683/2014, SFRH/BPD/101405/2014] Funding Source: FCT
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Iron is an essential nutrient for almost all living organisms, but is not easily made available. Hosts and pathogens engage in a fight for the metal during an infection, leading to major alterations in the host's iron metabolism. Important pathological consequences can emerge from the mentioned interaction, including anemia. Several recent reports have highlighted the alterations in iron metabolism caused by different types of infection, and several possible therapeutic strategies emerge, based on the targeting of the host's iron metabolism. Here, we review the most recent literature on iron metabolism alterations that are induced by infection, the consequent development of anemia, and the potential therapeutic approaches to modulate iron metabolism in order to correct iron-related pathologies and control the ongoing infection.
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