Journal
APL PHOTONICS
Volume 3, Issue 10, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.5040861
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Funding
- Australian Research Council [CE140100003, FT160100357]
- South Australian Government Department of State Development
- Australian Research Council Future Fellowship
- Australian Research Council Discovery Early Career Researcher Award
- Ramsay Fellowship
- University of Adelaide
- European Commission through the Seventh Framework Programme (FP7) [PIIF-GA-2013-623248]
- Australian Defence Science and Technology Group
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The probing of physiological processes in living organisms is a grand challenge that requires bespoke analytical tools. Optical fiber probes offer a minimally invasive approach to report physiological signals from specific locations inside the body. This perspective article discusses a wide range of such fiber probes developed at the Australian Research Council Centre of Excellence for Nanoscale BioPhotonics. Our fiber platforms use a range of sensing modalities, including embedded nanodiamonds for magnetometry, interferometric fiber cavities for refractive index sensing, and tailored metal coatings for surface plasmon resonance sensing. Other fiber probes exploit molecularly sensitive Raman scattering or fluorescence where optical fibers have been combined with chemical and immunosensors. Fiber imaging probes based on interferometry and computational imaging are also discussed as emerging in vivo diagnostic devices. We provide examples to illustrate how the convergence of multiple scientific disciplines generates opportunities for the fiber probes to address key challenges in real-time in vivo diagnostics. These future fiber probes will enable the asking and answering of scientific questions that were never possible before. (C) 2018 Author(s).
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