Journal
ONCOLOGY RESEARCH
Volume 25, Issue 2, Pages 241-248Publisher
COGNIZANT COMMUNICATION CORP
DOI: 10.3727/096504016X14742891049118
Keywords
Rab23; Proliferation; Migration; Invasion; Prostate cancer (PCa)
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Funding
- Project of Science and Technology Research of Henan Province Department of Education [15A320050]
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Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Glil. Furthermore, we found that the Glil inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.
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