Journal
ONCOLOGY REPORTS
Volume 37, Issue 4, Pages 2398-2404Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2017.5454
Keywords
USP39; colorectal cancer; metastasis
Categories
Funding
- National Natural Science Foundation of China [31300103, 31171306, 31371373, 31530046]
- Clinical Medical Center for Hepatobiliary Disease of Jiangsu Province [ZX201105]
- Clinical Medical Center for Digestive Disease of Jiangsu Province [BL2012001]
- Natural Science Foundation of Jiangsu Province [BK20151395]
- National Basic Research Program of China [2012CB524900]
- Open Fund of State Key Laboratory of Natural Medicines [SKLNMKF201606]
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In the present study we first examined the expression of USP39 protein using tissue array containing 90 colorectal cancer (CRC) tissues and 9 clinical samples and observed that it has significantly higher expression in cancer tissues as compared to the corresponding adjacent normal tissues. Also we tested USP39 expression level in four CRC cancer cell lines and identified that it indeed had higher expression in all these CRC cell lines. In addition its knockdown inhibited not only the cell growth of SW480 and HT29 cells but also the cell migration and invasion. Further analysis of its molecular mechanism suggested that the expression of four crucial proteins of Wnt/(beta-catenin pathway including beta-catenin TCF4 MMP2 and MMP9 was reduced as a result of USP39 knockdown. Taken together all these findings demonstrated that USP39 protein plays an important role in the growth and metastasis of colorectal cancer mainly through Wnt/beta-catenin pathway.
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