Journal
ONCOLOGY REPORTS
Volume 38, Issue 1, Pages 449-455Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2017.5646
Keywords
colon carcinoma; cytokine; myeloid-derived suppressor cell; regulatory T cells
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Funding
- Program to Disseminate Tenure Tracking System, MEXT, Japan
- Okayama Foundation for Science and Technology
- Ryobi Teien Memory Foundation
- Sanyo Hohso Foundation
- Japan Society for the Promotion of Science [15K11096, 15H03002]
- Hiroshima University
- Nagasaki University
- Fukushima Medical University
- Grants-in-Aid for Scientific Research [15H03002, 26293295, 17K01886, 15K11096] Funding Source: KAKEN
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To evaluate systemic immunity associated with tumor growth limited to a subcutaneous site versus growth proceeding at multiple tumor sites, we established syngeneic mouse subcutaneous and pulmonary tumor models by local subcutaneous and intravenous injection of colon carcinoma CT26 cells. We found that splenic myeloid-derived suppressor cell (MDSC) levels were significantly increased in the subcutaneous tumor model but not in the pulmonary tumor model. Furthermore, both CD4(+) and CD8(+) T cells as well as CD4(+) Foxp3(+) T cells were significantly decreased in the subcutaneous tumor model and were largely unchanged in the pulmonary tumor model. In addition, the subcutaneous model, but not the pulmonary model, displayed a Thl polarization bias. This bias was characterized by decreased IL-4, IL-9, and IL-10 production, whereas the pulmonary model displayed increased production of IL-W. These results suggest that the mode of tumor development has differential effects on systemic immunity that may, in turn, influence approaches to treatment of cancer patients.
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