Journal
FRONTIERS IN SYNAPTIC NEUROSCIENCE
Volume 10, Issue -, Pages -Publisher
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fnsyn.2018.00042
Keywords
NMDA receptor; long-term potentiation; hippocampus; calcium-permeable AMPA receptor; PKA
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Funding
- Brain Canada Foundation through the Canada Brain Research Fund
- Health Canada
- Medical Research Council (MRC)
- European Research Council (ERC)
- Canadian Institute for Health Research (CIHR) Foundation grant
- EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health
- Canada Research Chair
- CIHR [CIHR66975, 84256]
- National Honor Scientist Program of the National Research Foundation - Korea government
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Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
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