Journal
NANOTECHNOLOGIES IN RUSSIA
Volume 13, Issue 5-6, Pages 331-336Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1995078018030084
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FeNi nanotubes with a length of 12 m, a diameter of 400 nm, and a wall thickness of similar to 120 nm (obtained by template synthesis in the pores of polyethylene terephthalate ion-track membranes) are used to create a tool for the targeted delivery of drugs and genes. The possibility of coating their surface with a biocompatible polymer (polymethylmethacrylate) and the functionalization by the protein on the example of concanavalin A as a magnetic carrier for targeted delivery is demonstrated. To implement the system for the targeted delivery of drugs such as magnetic nanostructure + polymer coating + pharmaceutical agent based on FeNi nanotubes, a scheme for the phased functionalization of nanostructures is developed which includes three main stages: (1) passivation of the surface with the formation of OH groups on the surface of nanotubes through which (2) polymethylmethacrylate molecules are attached through carboxyl groups and (3) concanavalin A molecules are immobilized on the surface of the polymer film through amide groups.
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