Journal
GENOME BIOLOGY
Volume 19, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13059-018-1590-2
Keywords
Human gene count; GTEx; RNA sequencing; Transcriptome; Transcriptome assembly
Funding
- NCI NIH HHS [U24 CA210985] Funding Source: Medline
- NHGRI NIH HHS [R01 HG006677, R01-HG006677] Funding Source: Medline
- NIGMS NIH HHS [R01-GM083873, R01 GM083873] Funding Source: Medline
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We assembled the sequences from deep RNA sequencing experiments by the Genotype-Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts, called CHESS. The new database contains 42,611 genes, of which 20,352 are potentially protein-coding and 22,259 are noncoding, and a total of 323,258 transcripts. These include 224 novel protein-coding genes and 116,156 novel transcripts. We detected over 30 million additional transcripts at more than 650,000 genomic loci, nearly all of which are likely nonfunctional, revealing a heretofore unappreciated amount of transcriptional noise in human cells. The CHESS database is available at http://ccb.jhu.edu/chess.
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