Journal
OBESITY REVIEWS
Volume 18, Issue 6, Pages 647-659Publisher
WILEY
DOI: 10.1111/obr.12530
Keywords
myofibers; Obesity; signalling pathways; type 2 diabetes
Categories
Funding
- National Basic Research Program of China [2013CB127305, 2012CB124704]
- Nature Science Foundation of Hunan Province [S2014J504I]
- Youth Innovation Promotion Association CAS [2016326]
- Major Project of Hunan Province [2015NK1002]
- National Science and the Technology Ministry [2014BAD08B11]
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Mammalian skeletal muscles are composed of two major fibre types (I and II) that differ in terms of size, metabolism and contractile properties. In general, slow-twitch type I fibres are rich in mitochondria and have a greater insulin sensitivity than fast-twitch type II skeletal muscles. Although not widely appreciated, a forced induction of the slow skeletal muscle phenotype may inhibit the progress of obesity and diabetes. This potentially forms the basis for targeting slow/oxidative myofibers in the treatment of obesity. In this context, a better understanding of the molecular basis of fibre-type specification and plasticity may help to identify potential therapeutic targets for obesity and diabetes.
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