Journal
NUTRITION RESEARCH
Volume 43, Issue -, Pages 82-88Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.nutres.2017.05.010
Keywords
Abdominal obesity; Postprandial insulin resistance; Lipid metabolism; Liquid high-fat meal; Adipokines
Categories
Funding
- National Natural Science Foundation of China [81573144]
- National Key Research and Development Program of China [2016YFD0400604]
- Fundamental Research Funds for the Central Universities
- Graduate Research and Innovation Projects of Colleges in Jiangsu Province [KYLX15_0175]
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Abdominal obesity is associated with an increased risk of insulin resistance, which may be a potential contributor to dyslipidemia. However, the relationship between postprandial insulin resistance and lipid metabolism in abdominally obese subjects remains unknown. We hypothesized that postprandial dyslipidemia would be exaggerated in abdominally obese subjects with high postprandial insulin resistance. To test this hypothesis, serum glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein B were measured at baseline and postprandial state at 0.5,1, 2, 4, 6, and 8 hours after a liquid high-fat meal in non-abdominally obese controls (n = 44) and abdominally obese subjects with low (AOLPIR, n = 40), middle (n = 40), and high postprandial insulin resistance (AO-HPIR, n = 40) based on the tertiles ratio of the insulin to glucose areas under the curve (AUC). Their serum adipokines were tested at baseline only. Fasting serum leptin was higher (P < .05) in AO-HPIR than that in AO-LPIR and controls. Postprandial triglycerides AUC was higher (P < .05), whereas high-density lipoprotein cholesterol AUC was lower (P < .05), in AO-HPIR than those in AO-LPIR and controls. Postprandial AUCs for total cholesterol and apolipoprotein B were similar in abdominally obese subjects with different degrees of postprandial insulin resistance and controls. The present study indicated that the higher degree of postprandial insulin resistance, the more adverse lipid profiles in abdominally obese subjects, which provides insight into opportunity for screening in health. (C) 2017 Elsevier Inc. All rights reserved.
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