Journal
CEREBRAL CORTEX
Volume 28, Issue 12, Pages 4390-4402Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx297
Keywords
aging; bimanual; functional connectivity; motor performance; resting state
Categories
Funding
- KU Leuven Special Research Fund [C16/15/070]
- Research Foundation-Flanders (FWO) [132635, G.0708.14]
- Francqui Foundation
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement [703490]
- Wellcome Trust [101253/A/13/Z]
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Aging is typically associated with substantial declines inmotor functioning as well as robust changes in the functional organization of brain networks. Previous research has investigated the link between these 2 age-varying factors but examinations were predominantly limited to the functional organization within motor-related brain networks. Little is known about the relationship between age-related behavioral impairments and changes in functional organization at the whole brain (i.e., multiple network) level. This knowledge gap is surprising given that the decreased segregation of brain networks ( i.e., increased internetwork connectivity) can be considered a hallmark of the aging process. Accordingly, we investigated the association between declines in motor performance across the adult lifespan (20-75 years) and age-related modulations of functional connectivity within and between resting state networks. Results indicated that stronger internetwork resting state connectivity observed as a function of age was significantly related to worse motor performance. Moreover, performance had a significantly stronger association with the strength of internetwork as compared with intranetwork connectivity, including connectivity within motor networks. These findings suggest that age-related declines in motor performance may be attributed to a breakdown in the functional organization of large-scale brain networks rather than simply age-related connectivity changes within motor-related networks.
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