Journal
ACS OMEGA
Volume 3, Issue 12, Pages 17562-17572Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b02487
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Funding
- UGC, India
- IIT-Kanpur
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A simple synthetic route to access racemic 3,3-disubstituted propylamines in excellent yields (up to 95%) via Lewis acid catalyzed S(N)2-type ring opening of activated azetidines with electron-rich arenes and heteroarenes under mild conditions has been accomplished. The methodology is efficiently used for the racemic synthesis of an antimuscarinic drug, tolterodine, in four steps in 47% overall yield.
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