Effect of ultrasound-enhanced Nigella sativa seeds oil on wound healing: An animal model

Objectives: Nigella saliva oil, ultrasound, and moist-exposed burn ointment (MEBO) have been suggested as noninvasive treatments for a number of inflammatory conditions and to accelerate wound healing. The aim of this study was to evaluate the efficiency of pulsed and continuous modes of ultrasound either alone or through phonophoresis, with N. saliva oil, or MEBO ointment in the treatment of chemical burns. Methods: Thirty-five local rabbits were randomly divided into seven equal groups: pulsed ultrasound, continuous ultrasound, topical N. saliva oil, pulsed phonophoresis, continuous phonophoresis, topical MEBO ointment, and control group. Wound surface area was measured on days 0, 7, 14, and 21 using metric graph paper and photographs. Results: Significant differences were found between pre- and post-treatment wounds in all groups, except for the control group, in favor of the pulsed phonophoresis. In contrast, low results were found in favor of continuous ultrasound. Conclusion: Ultrasound, topical application of N. saliva oil, phonophoresis, and MEBO ointment have the potential to accelerate wound healing induced by chemical burns. Such treatment modalities may be used to treat wounds.