4.8 Article

The Proteins API: accessing key integrated protein and genome information

Journal

NUCLEIC ACIDS RESEARCH
Volume 45, Issue W1, Pages W539-W544

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx237

Keywords

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Funding

  1. National Human Genome Research Institute of the National Institutes of Health [3U41HG007822-02S1]
  2. BBSRC [BB/M011674/1]
  3. EMBL
  4. NIH grant via EMBL-EBI
  5. Biotechnology and Biological Sciences Research Council [BB/M011674/1] Funding Source: researchfish
  6. BBSRC [BB/M011674/1] Funding Source: UKRI

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The Proteins API provides searching and programmatic access to protein and associated genomics data such as curated protein sequence positional annotations from UniProtKB, as well as mapped variation and proteomics data from large scale data sources (LSS). Using the coordinates service, researchers are able to retrieve the genomic sequence coordinates for proteins in UniProtKB. This, the LSS genomics and proteomics data for UniProt proteins is programmatically only available through this service. A Swagger UI has been implemented to provide documentation, an interface for users, with little or no programming experience, to 'talk' to the services to quickly and easily formulate queries with the services and obtain dynamically generated source code for popular programming languages, such as Java, Perl, Python and Ruby. Search results are returned as standard JSON, XML or GFF data objects. The Proteins API is a scalable, reliable, fast, easy to use RESTful services that provides a broad protein information resource for users to ask questions based upon their field of expertise and allowing them to gain an integrated overview of protein annotations available to aid their knowledge gain on proteins in biological processes. The Proteins API is available at (http://www.ebi.ac.uk/proteins/api/doc).

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