Journal
NUCLEIC ACIDS RESEARCH
Volume 46, Issue D1, Pages D281-D287Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx1080
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Funding
- China Fundamental Research Funds for the Central Universities [2014QNA84]
- National Natural Science Foundation of China [31671373, 61401370, 61473232, 61772531, 11631014, 61501466]
- National Institute of Health [R01GM113245, R01CA124332]
- NATIONAL CANCER INSTITUTE [R01CA096512, R01CA197153, R01CA132637, R01CA213275] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [R01DE025465] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM113245] Funding Source: NIH RePORTER
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Methyltranscriptome is an exciting new area that studies the mechanisms and functions of methylation in transcripts. A knowledge base with the systematic collection and curation of context specific transcriptome-wide methylations is critical for elucidating their biological functions as well as for developing bioinformatics tools. Since its inception in 2014, the Met-DB (Liu, H., Flores, M.A., Meng, J., Zhang, L., Zhao, X., Rao, M.K., Chen, Y. and Huang, Y. (2015) MeT-DB: a database of transcriptome methylation in mammalian cells. Nucleic Acids Res., 43, D197-D203), has become an important resource for methyltranscriptome, especially in the N-6-methyl-adenosine (m(6)A) research community. Here, we report Met-DB v2.0, the significantly improved second version of Met-DB, which is entirely redesigned to focus more on elucidating context-specific m(6)A functions. Met-DB v2.0 has a major increase in context-specific m(6)A peaks and single-base sites predicted from 185 samples for 7 species from 26 independent studies. Moreover, it is also integrated with a new database for targets of m(6)A readers, erasers and writers and expanded with more collections of functional data. The redesigned Met-DB v2.0 web interface and genome browser provide more friendly, powerful, and informative ways to query and visualize the data. More importantly, MeT-DB v2.0 offers for the first time a series of tools specifically designed for understanding m(6)A functions. Met-DB V2.0 will be a valuable resource for m(6)A methyltranscriptome research. The Met-DB V2.0 database is available at http://compgenomics.utsa.edu/MeTDB/and http://www.xjtlu.edu.cn/metdb2.
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