Journal
NUCLEIC ACIDS RESEARCH
Volume 45, Issue W1, Pages W307-W314Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx336
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Funding
- Institut Universitaire de France
- French Governement Funds at UPMC [ANR-10-EQPX- 29-01]
- French Governement-Excellence Program 'Investissement d'Avenir' in Bioinformatics [MAPPING] [ANR-11-BINF-0003]
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Along protein sequences, co-evolution analysis identifies residue pairs demonstrating either a specific co-adaptation, where changes in one of the residues are compensated by changes in the other during evolution or a less specific external force that affects the evolutionary rates of both residues in a similar magnitude. In both cases, independently of the underlying cause, co-evolutionary signatures within or between proteins serve as markers of physical interactions and/or functional relationships. Depending on the type of protein under study, the set of available homologous sequences may greatly differ in size and amino acid variability. BIS2Analyzer, openly accessible at http://www.lcqb.upmc.fr/BIS2Analyzer/, is a web server providing the online analysis of coevolving amino-acid pairs in protein alignments, especially designed for vertebrate and viral protein families, which typically display a small number of highly similar sequences. It is based on BIS2, a re-mplemented fast version of the co-evolution analysis tool Blocks in Sequences (BIS). BIS2Analyzer provides a rich and interactive graphical interface to ease biological interpretation of the results.
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