Journal
NUCLEIC ACIDS RESEARCH
Volume 45, Issue 15, Pages 8676-8683Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx602
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Funding
- Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0420164029]
- National Sciences Foundation of China [21322208, 21572222]
- Innovative Team of Sichuan Province [2017TD0021]
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Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce singlestrand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells. Moreover, riboflavin is a promising leading compound for further drug design due to its inherent specific recognition of the G-T mismatch.
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