Journal
NUCLEIC ACIDS RESEARCH
Volume 45, Issue 14, Pages 8129-8141Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx565
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Funding
- National Institutes of Health [CA132755, CA130899, CA187209]
- Era of Hope Scholar Award from Department of Defense
- Research Scholar Award from Leukemia and Lymphoma Society
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Poly ADP-ribose polymerases (PARPs) catalyze massive protein poly ADP-ribosylation (PARylation) within seconds after the induction of DNA single- or double-strand breaks. PARylation occurs at or near the sites of DNA damage and promotes the recruitment of DNA repair factors via their poly ADP-ribose (PAR) binding domains. Several novel PAR-binding domains have been recently identified. Here, we summarize these and other recent findings suggesting that PARylation may be the critical event that mediates the first wave of the DNA damage response. We also discuss the potential for functional crosstalk with other DNA damage-induced post-translational modifications.
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