4.7 Article

A fluoride activated methylene blue releasing platform for imaging and antimicrobial photodynamic therapy of human dental plaque

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 93, Pages 13115-13118

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc07410k

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Funding

  1. NNSFC [21877013, 21671043]
  2. National Key R&D Program of China [2017YFA0205100]

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We report a F- activated methylene blue (MB) releasing platform for imaging and antimicrobial photodynamic therapy (aPDT). By utilizing this platform, one of the selected probes, FD-F3, displays a remarkable near-infrared fluorescence and absorption increase towards F- with good selectivity and low detection limit. This probe has been successfully applied for visualizing F- and performing F- activated aPDT in naturally grown human plaque biofilms.

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