Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 75, Issue 4, Pages 589-595Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-017-2715-6
Keywords
Phage; Intestinal epithelial cell; Immunity; Intestinal inflammatory disorder; Immunomodulation; Phage therapy
Categories
Funding
- National Science Center [DEC-2013/11/B/NZ1/02107, DEC-2015/17/N/NZ6/03520]
- Wroclaw Centre of Biotechnology, programme The Leading National Research Centre (KNOW)
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In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that-in addition to their established antibacterial activity-they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD.
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