Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 10, Issue 1, Pages 1132-1146Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b16000
Keywords
photodynamic therapy; photothermal therapy; nanoparticles; computed tomography; hypoxia
Funding
- National Key R&D Program of China [2017YFA0205400]
- National Natural Science Foundation of China [21474047, 51773089, 81671751, 81371516]
- Industry-University-Research Collaboration project of Jiangsu Province [BY2015041-01]
- Key Project and Outstanding Youth
- Medical Science and Technology Development Foundation Nanjing Department of Health [YKK15067]
- Jiangsu province key medical young talents, 13th Five-Year health promotion project of Jiangsu province [JH.2016-2020]
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The consumption of oxygen in photodynamic therapy (PDT) significantly exacerbates the degree of hypoxia in tumors, which not only impedes the therapeutic effect of PDT, but also drives local tumor recurrence. To relieve the PDT-induced hypoxia and improve the therapeutic outcome of PDT in cancer treatment, herein we reported a class of Bi2WO6 nanoparticles (NPs) as a robust multifunctional platform, which integrates the abilities for contrast-enhanced computed tomography (CT) imaging, photothermal therapy, and PDT in an oxygen-free manner. The as-obtained Bi2WO6 NPs with a mean diameter of 5.2 nm are stable in phosphate-buffered saline and an in vivo microenvironment-mimicking buffer. The location of the solid tumor could be accurately positioned using Bi2WO6-enhanced CT with higher spatial resolution. After being irradiated with an 808 nm laser, these Bi2WO6 NPs could realize CT-guided local photothermal ablation of the tumor. Meanwhile, *OH radicals were generated simultaneously from the treatment without consuming an oxygen molecule, which enabled these Bi2WO6 NPs to exert photodynamic killing effect in an oxygen-free manner during cancer therapy. Remarkable tumor suppression was observed in mice bearing the HeLa xenograft, supporting the promising application of these multifunctional Bi2WO6 NPs in the combat against cancers through synergistic photothermal and oxygen-free PDT treatment.
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